Cellular and molecular mechanisms of renal fibrosis
نویسندگان
چکیده
منابع مشابه
[Cellular and molecular mechanisms of fibrosis].
Fibrosis is defined by the overgrowth, hardening, and/or scarring of various tissues and is attributed to excess deposition of extracellular matrix components including collagen. Fibrosis is the end result of chronic inflammatory reactions induced by a variety of stimuli including persistent infections, autoimmune reactions, allergic responses, chemical insults, radiation, and tissue injury. Al...
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Organ fibrosis is a pathological condition associated with chronic inflammatory diseases. In fibrosis, excessive deposition of extracellular matrix (ECM) severely impairs tissue architecture and function, eventually resulting in organ failure. This process is mediated primarily by the induction of myofibroblasts, which produce large amounts of collagen I, the main component of the ECM. Accordin...
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ژورنال
عنوان ژورنال: Nature Reviews Nephrology
سال: 2011
ISSN: 1759-5061,1759-507X
DOI: 10.1038/nrneph.2011.149